Archival ReportAre Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-Based Functional Magnetic Resonance Imaging Meta-analysis
Section snippets
Inclusion of Studies
The meta-analysis was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines (39) (see Table S1 for the checklist). The protocol for this meta-analysis was not preregistered. We performed a comprehensive literature search using PubMed and Web of Science. The search (which identified records published until April 15, 2020) used a combination of terms constructed according to 4 stems relating to 1) schizophrenia (schizophren∗,
Results
Whole-brain maps of within- and between-group meta-analyses are available on NeuroVault (52) for both frequentist and Bayesian analyses (https://neurovault.org/collections/CRLVVOUU/).
Discussion
Our meta-analysis aimed to investigate whether brain activation in response to negative emotional stimuli could be considered as an endophenotype of schizophrenia. Results showed that healthy control subjects and individuals at risk of schizophrenia present a remarkably similar pattern of brain activation in response to processing negative emotional stimuli. These similarities were observed in salient regions of the emotion processing network including the amygdala, thalamus, and inferior
Acknowledgments and Disclosures
AMF was supported by the Fondation Pierre Deniker. EF was supported by the Fondation de France. GS was supported by the Agence Nationale de la Recherche (Grant No. ANR-19-CE37-0012-01) and the Fondation NRJ-Institut de France.
The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
AMF and GS have full access to
References (79)
- et al.
Humanistic burden in schizophrenia: A literature review
J Psychiatr Res
(2014) - et al.
Impaired facial emotion perception in schizophrenia: A meta-analysis
Psychiatry Res
(2010) - et al.
Meta-analysis of functional neuroimaging studies of emotion perception and experience in schizophrenia
Biol Psychiatry
(2012) - et al.
Abnormal brain activation during threatening face processing in schizophrenia: A meta-analysis of functional neuroimaging studies
Schizophr Res
(2018) - et al.
Social cognition in first-degree relatives of people with schizophrenia: A meta-analysis
Psychiatry Res
(2013) - et al.
Systematic review and meta-analysis of the relationship between genetic risk for schizophrenia and facial emotion recognition
Schizophr Res
(2020) - et al.
Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: A population-based study
Lancet
(2009) - et al.
Social cognitive functioning in prodromal psychosis: A meta-analysis
Schizophr Res
(2015) - et al.
Facial affect recognition and social functioning among individuals with varying degrees of schizotypy
Psychiatry Res
(2017) - et al.
Corticolimbic dysfunction during facial and prosodic emotional recognition in first-episode psychosis patients and individuals at ultra-high risk
Neuroimage Clin
(2016)
Decreased neural response for facial emotion processing in subjects with high genetic load for schizophrenia
Prog Neuropsychopharmacol Biol Psychiatry
Exaggerated brain activation during emotion processing in unaffected siblings of patients with schizophrenia
Biol Psychiatry
Functional activation abnormalities during facial emotion perception in schizophrenia patients and nonpsychotic relatives
Schizophr Res
Neural correlates of emotional processing in psychosis risk and onset – A systematic review and meta-analysis of fMRI studies
Neurosci Biobehav Rev
Altered fronto-limbic activity in children and adolescents with familial high risk for schizophrenia
Psychiatry Res
Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study
Schizophr Res
Facial emotion processing in patients with schizophrenia and their non-psychotic siblings: A functional magnetic resonance imaging study
Schizophr Res
Increased neural response related to neutral faces in individuals at risk for psychosis
Neuroimage
A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps
Eur Psychiatry
Meta-analysis of neuroimaging data: A comparison of image-based and coordinate-based pooling of studies
Neuroimage
Voxel-based meta-analysis via permutation of subject images (PSI): Theory and implementation for SDM [published correction appears in Neuroimage 2021; 231:117859]
Neuroimage
Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference
Neuroimage
Altered activation and functional connectivity of neural systems supporting cognitive control of emotion in psychosis proneness
Schizophr Res
Ten simple rules for neuroimaging meta-analysis
Neurosci Biobehav Rev
PRISMA 2020 – An updated checklist for systematic reviews and meta-analyses
Neurosci Biobehav Rev
Abnormal effective fronto-limbic connectivity during emotion processing in schizophrenia
Prog Neuropsychopharmacol Biol Psychiatry
Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry
J Clin Epidemiol
Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia
Schizophr Res
Functional mapping of dynamic happy and fearful facial expressions in young adults with familial risk for psychosis – Oulu Brain and Mind Study
Schizophr Res
Facial emotion perception in schizophrenia: A meta-analytic review
Schizophr Bull
Vulnerability—A new view of schizophrenia
J Abnorm Psychol
The fragile brain: Stress vulnerability, negative affect and GABAergic neurocircuits in psychosis
Schizophr Bull
Amygdala recruitment in schizophrenia in response to aversive emotional material: A meta-analysis of neuroimaging studies
Schizophr Bull
Emotion recognition and theory of mind in schizophrenia: A meta-analysis of neuroimaging studies
World J Biol Psychiatry
Evidence of diagnostic specificity in the neural correlates of facial affect processing in bipolar disorder and schizophrenia: A meta-analysis of functional imaging studies
Psychol Med
Facial emotion processing in schizophrenia: A meta-analysis of functional neuroimaging data
Schizophr Bull
Limbic hyperactivity in response to emotionally neutral stimuli in schizophrenia: A neuroimaging meta-analysis of the hypervigilant mind
Am J Psychiatry
Emotion processing in persons at risk for schizophrenia
Schizophr Bull
The psychosis high-risk state: A comprehensive state-of-the-art review
JAMA Psychiatry
Cited by (5)
Unique Challenges in Biomarkers for Psychotic Disorders
2024, Brain SciencesThe Risk for Schizophrenia–Bipolar Spectrum: Does the Apple Fall Close to the Tree? A Narrative Review
2023, International Journal of Environmental Research and Public HealthThe Neural Correlates of the Social Perception Dysfunction in Schizophrenia: An fMRI Study
2023, Neuropsychiatric Disease and Treatment
EF and GS contributed equally to this work as joint last authors.